p53 Signaling
The p53 (TP53) tumor suppressor protein is a key transcriptional regulator that responds to a variety of cellular stresses such as DNA damage, UV irradiation, and hypoxia. p53 regulates key cellular processes such as DNA repair, cell-cycle progression, angiogenesis, and apoptosis. These p53-dependent pathways shut down damaged cells, either through apoptosis or cell-cycle arrest. Loss of p53 function is thought to be a contributing factor in the majority of cancer cases....
Pathway Summary
The p53 (TP53) tumor suppressor protein is a key transcriptional regulator that responds to a variety of cellular stresses such as DNA damage, UV irradiation, and hypoxia. p53 regulates key cellular processes such as DNA repair, cell-cycle progression, angiogenesis, and apoptosis. These p53-dependent pathways shut down damaged cells, either through apoptosis or cell-cycle arrest. Loss of p53 function is thought to be a contributing factor in the majority of cancer cases.
p53 Signaling Genes list
Explore Genes related to p53 Signaling
ADGRB1adhesion G protein-coupled receptor B1 AKT1AKT serine/threonine kinase 1 AKT2AKT serine/threonine kinase 2 AKT3AKT serine/threonine kinase 3 APAF1apoptotic peptidase activating factor 1 ATMATM serine/threonine kinase ATRATR serine/threonine kinase BAXBCL2 associated X, apoptosis regulator BBC3BCL2 binding component 3 BCL2BCL2 apoptosis regulator BCL2L1BCL2 like 1 BIRC5baculoviral IAP repeat containing 5 BRCA1BRCA1 DNA repair associated CASP6caspase 6 CCND1cyclin D1 CCND2cyclin D2 CCNG1cyclin G1 CCNKcyclin K CDK2cyclin dependent kinase 2 CDK4cyclin dependent kinase 4 CDKN1Acyclin dependent kinase inhibitor 1A CHEK1checkpoint kinase 1 CHEK2checkpoint kinase 2 COQ8Acoenzyme Q8A CSNK1Dcasein kinase 1 delta CTNNB1catenin beta 1 DRAM1DNA damage regulated autophagy modulator 1 E2F1E2F transcription factor 1 EP300E1A binding protein p300 FASFas cell surface death receptor GADD45Agrowth arrest and DNA damage inducible alpha GADD45Bgrowth arrest and DNA damage inducible beta GADD45Ggrowth arrest and DNA damage inducible gamma GMLglycosylphosphatidylinositol anchored molecule like GNL3G protein nucleolar 3 GSK3Bglycogen synthase kinase 3 beta HDAC1histone deacetylase 1 HDAC9histone deacetylase 9 HIF1Ahypoxia inducible factor 1 subunit alpha HIPK2homeodomain interacting protein kinase 2 JMYjunction mediating and regulatory protein, p53 cofactor JUNJun proto-oncogene, AP-1 transcription factor subunit KAT2Blysine acetyltransferase 2B MAPK14mitogen-activated protein kinase 14 MAPK8mitogen-activated protein kinase 8 MDM2MDM2 proto-oncogene MDM4MDM4 regulator of p53 MED1mediator complex subunit 1 PCNAproliferating cell nuclear antigen PERPp53 apoptosis effector related to PMP22 PIAS1protein inhibitor of activated STAT 1 PIDD1p53-induced death domain protein 1 PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha PIK3C2Bphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2Gphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C3phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CBphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma PIK3R1phosphoinositide-3-kinase regulatory subunit 1 PIK3R2phosphoinositide-3-kinase regulatory subunit 2 PIK3R3phosphoinositide-3-kinase regulatory subunit 3 PIK3R4phosphoinositide-3-kinase regulatory subunit 4 PIK3R5phosphoinositide-3-kinase regulatory subunit 5 PIK3R6phosphoinositide-3-kinase regulatory subunit 6 PLAGL1PLAG1 like zinc finger 1 PMAIP1phorbol-12-myristate-13-acetate-induced protein 1 PMLPML nuclear body scaffold PPP1R13Bprotein phosphatase 1 regulatory subunit 13B PRKDCprotein kinase, DNA-activated, catalytic subunit PTENphosphatase and tensin homolog RB1RB transcriptional corepressor 1 RPRMreprimo, TP53 dependent G2 arrest mediator homolog RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B SCO2synthesis of cytochrome C oxidase 2 SERPINB5serpin family B member 5 SERPINE2serpin family E member 2 SFNstratifin SIRT1sirtuin 1 SNAI2snail family transcriptional repressor 2 ST13ST13 Hsp70 interacting protein STAG1stromal antigen 1 THBS1thrombospondin 1 TIGARTP53 induced glycolysis regulatory phosphatase TNFRSF10ATNF receptor superfamily member 10a TNFRSF10BTNF receptor superfamily member 10b TOPBP1DNA topoisomerase II binding protein 1 TP53tumor protein p53 TP53AIP1tumor protein p53 regulated apoptosis inducing protein 1 TP53BP2tumor protein p53 binding protein 2 TP53I3tumor protein p53 inducible protein 3 TP53INP1tumor protein p53 inducible nuclear protein 1 TP63tumor protein p63 TRIM29tripartite motif containing 29 WT1WT1 transcription factor