Dysregulation of the adhesion and diapedesis processes can result in a variety of health issues, including chronic inflammation, autoimmune diseases, or impaired immune responses. Excessive adhesion can lead to chronic inflammation and tissue damage. When granulocytes adhere excessively to blood vessel walls, they can release inflammatory molecules, causing prolonged inflammation that is associated with conditions such as atherosclerosis and inflammatory bowel diseases.
Conversely, insufficient adhesion can result in compromised immune responses. If granulocytes fail to adhere efficiently and migrate to sites of infection or injury, the body's ability to combat pathogens becomes compromised. This can lead to an increased susceptibility to infections and slower wound healing.
Dysregulated adhesion and diapedesis can also exacerbate autoimmune diseases by contributing to tissue damage and the immune system's misdirected attacks on the body's own tissues.