Explore Pathways
Over 400 well-characterized and interactive metabolic and cell signaling pathways
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A
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Acute Myeloid Leukemia Signaling
- Acute Phase Response Signaling
- Adipogenesis pathway
- Adrenomedullin signaling pathway
- Agranulocyte Adhesion and Diapedesis
- Agrin Interactions at Neuromuscular Junction
- Airway Inflammation in Asthma
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Aldosterone Signaling in Epithelial Cells
- Allograft Rejection Signaling
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- AMPK Signaling
- Amyloid Processing
- Amyotrophic Lateral Sclerosis Signaling
- Androgen Signaling
- Angiopoietin Signaling
- Antigen Presentation Pathway
- Antioxidant Action of Vitamin C
- Antiproliferative Role of Somatostatin Receptor 2
- Antiproliferative Role of TOB in T Cell Signaling
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiac Fibroblast Signaling Pathway
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Apelin Liver Signaling Pathway
- Apelin Muscle Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Apoptosis Signaling Pathway
- April Mediated Signaling
- Arsenate Detoxification I (Glutaredoxin)
- Aryl Hydrocarbon Receptor Signaling
- Assembly of RNA Polymerase I Complex
- Assembly of RNA Polymerase II Complex
- Assembly of RNA Polymerase III Complex
- Atherosclerosis Signaling
- ATM Signaling
- Autoimmune Thyroid Disease Signaling
- Autophagy
- Axonal Guidance Signaling
C
- Calcium Signaling
- Calcium-induced T Lymphocyte Apoptosis
- cAMP-mediated signaling
- Cancer Drug Resistance By Drug Efflux
- Cardiac Hypertrophy Signaling
- Cardiac β-adrenergic Signaling
- Cardiomyocyte Differentiation via BMP Receptors
- Caveolar-mediated Endocytosis Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CD27 Signaling in Lymphocytes
- CD28 Signaling in T Helper Cells
- CD40 Signaling
- Cdc42 Signaling
- CDK5 Signaling
- Cell Cycle Control of Chromosomal Replication
- Cell Cycle Regulation by BTG Family Proteins
- Cell Cycle: G1/S Checkpoint Regulation
- Cell Cycle: G2/M DNA Damage Checkpoint Regulation
- Cellular Effects of Sildenafil (Viagra)
- Ceramide Biosynthesis
- Ceramide Signaling
- Chemokine Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Chronic Myeloid Leukemia Signaling
- Circadian Rhythm Signaling
- Clathrin-mediated Endocytosis Signaling
- Cleavage and Polyadenylation of Pre-mRNA
- CNTF Signaling
- Coagulation System
- Colorectal Cancer Metastasis Signaling
- Communication between Innate and Adaptive Immune Cells
- Complement System
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
- Crosstalk between Dendritic Cells and Natural Killer Cells
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- CXCR4 Signaling
- Cyclins and Cell Cycle Regulation
- Cytotoxic T cells in Apoptosis
D
- Death Receptor Signaling
- Dendritic Cell Maturation
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Diphthamide Biosynthesis
- DNA damage-induced 14-3-3σ Signaling
- DNA Methylation and Transcriptional Repression Signaling
- DNA Mismatch Repair (MMR) in Eukaryotes
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
E
- EGF Signaling
- Eicosanoid Signaling
- EIF2 Signaling
- Embryonic Stem Cell Differentiation into Cardiac Lineages
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endometrial Cancer Signaling
- Endoplasmic Reticulum Stress Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- Ephrin A Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- ErbB Signaling
- ErbB2-ErbB3 Signaling
- ErbB4 Signaling
- ERK/MAPK Signaling
- ERK5 Signaling
- Erythropoietin Signaling
- Estrogen Receptor Signaling
- Estrogen-Dependent Breast Cancer Signaling
- Estrogen-mediated S-phase Entry
- Eumelanin Biosynthesis
- Extrinsic Prothrombin Activation Pathway
G
- G Beta Gamma Signaling
- G Protein Signaling Mediated by Tubby
- G-Protein Coupled Receptor Signaling
- GABA Receptor Signaling
- GADD45 Signaling
- Gap Junction Signaling
- GDNF Family Ligand-Receptor Interactions
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Glioma Signaling
- Glucocorticoid Receptor Signaling
- Glutamate Receptor Signaling
- Glutaryl-CoA Degradation
- GM-CSF Signaling
- GNRH Signaling
- GP6 Signaling Pathway
- GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Graft-versus-Host Disease Signaling
- Granulocyte Adhesion and Diapedesis
- Granzyme A Signaling
- Granzyme B Signaling
- Growth Hormone Signaling
- Gustation Pathway
- Gα12/13 Signaling
- Gαi Signaling
- Gαq Signaling
- Gαs Signaling
H
- Hematopoietic Stem Cells and Hematopoiesis
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HER-2 Signaling in Breast Cancer
- Hereditary Breast Cancer Signaling
- HGF Signaling
- HIF1α Signaling
- HIPPO signaling
- HMGB1 Signaling
- Homologous Recombination (HR) and the Repair of DNA Double-Strand Breaks
- Human Embryonic Stem Cell Pluripotency
- Huntington's Disease Signaling
- Hypoxia Signaling in the Cardiovascular System
- Hypusine Biosynthesis
I
- iCOS-iCOSL Signaling in T Helper Cells
- IGF-1 Signaling
- IL-1 Signaling
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- IL-15 Production
- IL-15 Signaling
- IL-17 Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Fibroblasts
- IL-17A Signaling in Gastric Cells
- IL-2 Signaling
- IL-22 Signaling
- IL-3 Signaling
- IL-4 Signaling
- IL-6 Signaling
- IL-7 Signaling Pathway
- IL-8 Signaling
- IL-9 Signaling
- ILK Signaling
- Induction of Apoptosis by HIV1
- Inflammasome pathway
- Inhibition of Angiogenesis by TSP1
- Inhibition of Matrix Metalloproteases
- iNOS Signaling
- Insulin Receptor Signaling
- Integrin Signaling
- Interferon Signaling
- Intrinsic Prothrombin Activation Pathway
- Iron homeostasis signaling pathway
- Isoleucine Degradation I
M
- Macropinocytosis Signaling
- Maturity Onset Diabetes of Young (MODY) Signaling
- Mechanisms of Viral Exit from Host Cells
- Melanocyte Development and Pigmentation Signaling
- Melanoma Signaling
- Melatonin Degradation III
- Melatonin Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Mitochondrial Dysfunction
- Mitotic Roles of Polo-Like Kinase
- Molecular Mechanisms of Cancer
- Molybdenum Cofactor Biosynthesis
- Mouse Embryonic Stem Cell Pluripotency
- MSP-RON Signaling Pathway
- mTOR Signaling
- Myc Mediated Apoptosis Signaling
N
- NADH Repair
- Natural Killer Cell Signaling
- Netrin Signaling
- Neuregulin Signaling
- Neuroinflammation Signaling Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Neuroprotective Role of THOP1 in Alzheimer's Disease
- Neurotrophin/TRK Signaling
- NF-κB Activation by Viruses
- NF-κB Signaling
- NGF Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- nNOS Signaling in Neurons
- nNOS Signaling in Skeletal Muscle Cells
- Non-Homologous End Joining (NHEJ) in DNA Double-Strand Break Repair
- Non-Small Cell Lung Cancer Signaling
- Notch Signaling
- NRF2-mediated Oxidative Stress Response
- Nucleotide Excision Repair (NER) in Eukaryotes
- Nur77 Signaling in T Lymphocytes
P
- P2Y Purinergic Receptor Signaling Pathway
- p38 MAPK Signaling
- p53 Signaling
- p70S6K Signaling
- PAK Signaling
- Pancreatic Adenocarcinoma Signaling
- Parkinson's Signaling
- Pathogenesis of Multiple Sclerosis
- Paxillin Signaling
- PCP pathway
- PDGF Signaling
- PEDF Signaling
- Phagosome Formation
- Phagosome Maturation
- Phospholipase C Signaling
- Phototransduction Pathway
- PI3K Signaling in B Lymphocytes
- PI3K/AKT Signaling
- PKCθ Signaling in T Lymphocytes
- Pluripotent Stem Cells and Hematopoiesis
- Polyamine Regulation in Colon Cancer
- PPAR Signaling
- PPARα/RXRα Activation
- Primary Immunodeficiency Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Prolactin Signaling
- Prostate Cancer Signaling
- Protein Kinase A Signaling
- Protein Ubiquitination Pathway
- PTEN Signaling
- PXR/RXR Activation
R
- Rac Signaling
- RAN Signaling
- RANK Signaling in Osteoclasts
- RAR Activation
- Reelin Signaling in Neurons
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Relaxin Signaling
- Remodeling of Epithelial Adherens Junctions
- Renal Cell Carcinoma Signaling
- Renin-Angiotensin Signaling
- Retinoic acid Mediated Apoptosis Signaling
- RhoA Signaling
- RhoGDI Signaling
- Role of BRCA1 in DNA Damage Response
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of IL-17A in Arthritis
- Role of IL-17A in Psoriasis
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of NFAT in Cardiac Hypertrophy
- Role of NFAT in Regulation of the Immune Response
- Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of p14/p19ARF in Tumor Suppression
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of PKR in Interferon Induction and Antiviral Response
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Role of Tissue Factor in Cancer
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
S
- SAPK/JNK Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Sirtuin Signaling Pathway
- Small Cell Lung Cancer Signaling
- Sonic Hedgehog Signaling
- Sperm Motility
- Sphingosine-1-phosphate Signaling
- SPINK1 General Cancer Pathway
- SPINK1 Pancreatic Cancer Pathway
- STAT3 Pathway
- Sumoylation Pathway
- Superpathway of Melatonin Degradation
- Superpathway of Methionine Degradation
- Synaptic Long Term Depression
- Synaptic Long Term Potentiation
- Systemic Lupus Erythematosus Signaling
T
- T Cell Receptor Signaling
- T Helper Cell Differentiation
- Tec Kinase Signaling
- Telomerase Signaling
- Telomere Extension by Telomerase
- Tetrahydrobiopterin Biosynthesis II
- TGF-β Signaling
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th17 Activation Pathway
- Th2 Pathway
- The Visual Cycle
- Thrombin Signaling
- Thrombopoietin Signaling
- Thyroid Cancer Signaling
- Thyroid Hormone Biosynthesis
- Thyroid Hormone Metabolism I (via Deiodination)
- Thyronamine and Iodothyronamine Metabolism
- Tight Junction Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- Toll-like Receptor Signaling
- TR/RXR Activation
- Transcriptional Regulatory Network in Embryonic Stem Cells
- TREM1 Signaling
- Tryptophan Degradation III (Eukaryotic)
- Tumoricidal Function of Hepatic Natural Killer Cells
- TWEAK Signaling
- Type I Diabetes Mellitus Signaling
- Type II Diabetes Mellitus Signaling