Target List
Apoptosis
ABL1, AKT1, APAF1, BAD, BAK1, BAX, BCL2, BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L11, BID, BIRC3 (c-IAP2), CASP1 (ICE), CASP3, CASP7, CASP8 (FLICE), CASP9, CD40 (TNFRSF5), CD40LG, CFLAR (CASPER), FADD, FAS, FASLG (TNFSF6), GADD45A, MCL1, TNF, TNFRSF10A (TRAIL-R), TNFRSF10B (DR5), TNFRSF1A (TNFR1), TNFSF10 (TRAIL), TP53 (p53), XIAP
Necrosis
ATP6V1G2, BMF, CCDC103, CD300LD, CLEC18A, COMMD4, CYLD, DEFB1, DPYSL4, EIF5B, FOXI1, GALNT5, GRB2, HOXA3, HSPBAP1, JPH3, KCNIP1, MAG, NUDT13, OR10J3, PARP2, PVR, RAB25, S100A7A, SPATA2, SYCP2, MACO1, TNFAIP8L1, TNFRSF1A (TNFR1), TXNL4B
DNA Damage & Repair
APEX1, ATM, ATR, BRCA1, BRCA2, CDKN1A (p21CIP1, WAF1), CHEK1, CHEK2 (RAD53), DDIT3 (GADD153, CHOP), ERCC1, ERCC2 (XPD), ERCC3 (XPB), ERCC5, ERCC6, GADD45A, LIG4, MDM2, MGMT (AGT), MLH1, MSH2, OGG1, PARP1 (ADPRT1), PCNA, PRKDC, RAD51, TP53 (p53), XPA, XPC, XRCC1, XRCC5
Mitochondrial Energy Metabolism
ACLY, ACO1, ACO2, COX6B1, COX8A, CS, CYC1, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH1B, MDH2, OGDH, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, UCP1, UCP2, UCP3
Fatty Acid Metabolism
ACAA1, ACAA2, ACAD11, ACAD9, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOT1, ACOT12, ACOT6, ACOT7, ACOT8, ACOT9, ACOX1, ACOX2, ACOX3, BDH2, CPT1A, CPT1B, CPT2, CRAT, CROT, DECR1, ECHS1, EHHADH, GCDH, HADHA
Oxidative Stress & Antioxidant Response
AASS, CAT, CTSB, DHCR24, DUOX1, DUOX2, EPX, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, IDH1, MPO, NQO1, NUDT1, NUDT15, PPP1R15B, PRDX1, PRDX2, PRDX6 (AOP2), SOD1, TPO, TXNIP, TXNRD2, UCP3
Heat Shock Response
CRYAA, CRYAB, DNAJA1, DNAJA2, DNAJA3, DNAJB1, DNAJB6, DNAJC3, DNAJC5, DNAJC6, HSF1 (TCF5), HSF2, HSP90AA1, HSP90AB1, HSP90B1, HSPA1A (HSP70-1A), HSPA1B, HSPA1L, HSPA2, HSPA4 (HSP70), HSPA5 (GRP78), HSPA8, HSPA9, HSPB1 (HSP27), HSPB2, HSPB6, HSPB8, HSPD1, HSPE1, HSPH1 (HSP105), TCP1
Endoplasmic Reticulum Stress & Unfolded Protein Response
AMFR, ATF4, ATF6, BAX, DDIT3 (GADD153, CHOP), DERL1, EDEM1, EDEM3, EIF2AK3, ERN2, ERO1A (ERO1L), ERO1B (ERO1LB), FBXO6, GADD45A, HERPUD1, HTRA2, HTRA4, MBTPS1, MBTPS2, NPLOC4, NUCB1, OS9, PFDN5, SEC62, SEL1L, SELENOS, SERP1, SYVN1, UBE2G2, UBE2J2, UBXN4, VCP, XBP1
Cytochrome P450s & Phase I Drug Metabolism
CYP1A1, CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, ESD, FMO2, FMO3, FMO4, FMO5, MAOA, MAOB
Steatosis
ACACA, ADK, ALDH2, AQP4, CD36, COMT, CYP2E1, CYP7B1, DNM1, ENO1, FAS, FASN, GPD1, HAAO, HADHB, KHK, LMNA, LPL, LY6D, MAPK8 (JNK1), MTTP, PCCA, PNPLA3, PPARA, RETN, SCD, SREBF1, SYT1, TFF3, VCP
Cholestasis
ABCB1 (MDR1, PGY1), ABCB4, ABCC1 (MRP1), ABCC2 (MRP2, cMOAT), ABCC3 (MRP3, MOAT-D), APOE, ATP8B1, CYP3A4, CYP7A1, DLAT, ESR1 (ERα), HLA-DRB1, ICAM1, IL10, IL1B, IL2, IL6, JAG1, MPO, NR1H4, NUP210, SLC51A, SLC51B, PDYN, RDX, SLC10A1, TGFB1, TNF
Phospholipidosis
ABCB1 (MDR1, PGY1), ALDH1A1 (RALDH1), ASAH1, ASNS, CES2, CTSB, EPHX1, FABP1, TIMM10B, GSTM4, HPN, INHBE, LSS, MANBA, MLX, MRPS18B, NR0B2, POR, S100A8, MSMO1, SERPINA3, SLC2A3, SLCO1A2, SMPD1, STBD1, TAGLN, UGT1A1, UGT2A1, UGT2B4, WIPI1
Immunotoxicity
ADH1C, AHR, AHSG, ALB, APOA5, APOF, C3, C9, CASP3, CD19, CD4, CD44, CD80, CD86, CD8A, CTSE, CYP1A1, CYP3A4, EP300, F2 (Thrombin), FABP1, FAS, GPT, GSTA3, HPX, HRG, HSPA5 (GRP78), IFNA1, IFNG, IL10, IL13, IL1A, IL1B, IL2, IL4, IL5, IL6, ITGAX, KLF1, LYZ, METAP2, MKI67, NFKB1, NR5A2, PON1, POU3F3, PTGS2 (COX2), PTPRC, SOD1, TNF, TRIM10, UBQLN2