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GeneGlobe ID: JHS-004Z | Cat. No.: | QIAseq RNA Fusion XP Panels

QIAseq RNA Fusion XP Lymphoma Panel

Kit containing ALL reagents (except indexes) for fusion and gene expression profiling by digital RNAseq

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Product Specification

Target List

Covers specific sides of specific exons of the targeted genes based on the Human GRCh38 genome build.Analyzes the expression of the targeted genes.Covers specific hotspots of the targeted genes based on the Human GRCh38 genome build.

Acute Lymphoblastic Lymphomas
CREBBP (CBP)KMT2AMLLT10MYCP2RY8PRDM16STIL
Anaplastic Large Cell Lymphomas
ADGRG7ALKATICCLTCMSNMYCNPM1TFGTPM3TPM4ALKCDKN2A (P16INK4A)DNMT3ANRASSTAT3
Angioimmunoblastic T Cell Lymphomas
CD28CTLA4FIP1L1PDGFRAALKAPCARID1AASXL1ATMBRAFCDKN2A (P16INK4A)CREBBP (CBP)CTNNB1DNMT3AEZH2FBXW7IDH2JAK1JAK3KIT (CD117)KMT2DKRASMED12PLCG1RHOASTAT3WT1XPO1ZFHX3
Burkitt Lymphomas
BCL6MYCPBX1TCF3APCARID1AATMCD79BCDKN2A (P16INK4A)CREBBP (CBP)FBXW7HLA-AID3KRASMYCMYD88NRASPAX5PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PTENRHOASRSF2
Diffuse Large B Cell Lymphomas (DLBCL)
ALKBCL11ABCL6CCND3CIITACLTCIGLL5MAPK13 (p38delta)MYCNPM1PIM1RELSQSTM1TBL1XR1TOMM40TP63ALKAMER1APCARID1AASXL1ATMB2MBCL2BCORBRAFBTKCD79BCDKN2A (P16INK4A)CNOT3CREBBP (CBP)CTNNB1CXCR4DNMT3AEZH2FBXW7HLA-AID3IDH2IRS4JAK1JAK3KIT (CD117)KMT2DKRASMAP2K1MED12MSNMYCMYD88NCOR1NFKBIENOTCH2NRASNSD2PAX5PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PLCG1POT1PPM1DPTENRGS7RHOASF3B1SMOSRSF2STAT3STAT5BSTAT6TERTTRRAPWT1XPO1ZFHX3ZNF479
Follicular Lymphomas
AFF3BCL2BCL6CIITAMYCTBL1XR1TP63AMER1ARID1AATMB2MBCL2BCORBRAFBTKCD79BCDKN2A (P16INK4A)CREBBP (CBP)CXCR4DNMT3AEZH2FBXW7ID3IDH2KMT2DMAP2K1MED12MYD88NOTCH2NRASPIK3R1 (p85-ALPHA)PPM1DPTENRGS7RHOASRSF2STAT6ZMYM3
Hodgkin Lymphomas
ALKCIITAJAK2NPM1SEC31AARID1AASXL1B2MBCORCDKN2A (P16INK4A)DNMT3AEZH2NFKBIENRASPAX5PIK3R1 (p85-ALPHA)PPM1DSF3B1
Inflammatory Myofibroblastic Tumors
ALKDCTN1
Lymphoblastic Lymphomas
BCRETV6FGFR1NOTCH1PBX1
Lymphoblastic T Cell Lymphomas
BCRETV6FGFR1FIP1L1LYNPDGFRA
Mantle Cell Lymphomas
CCND3MYCARID1AASXL1ATMB2MBCORBRAFBTKCDKN2A (P16INK4A)CREBBP (CBP)DNMT3AIDH2KMT2DKRASMED12NCOR1NFKBIENOTCH2NRASNSD2PAX5POT1PPM1DPTENSTAT3TERTZFHX3
Mediastinal Large B Cell Lymphomas (MLBL)
CIITAPDCD1LG2
Mediastinal Large B-Cell Lymphomas
CIITAPDCD1LG2
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas
BCL6BIRC3 (c-IAP2)CCND3MALT1MYCMYD88NOTCH2
Peripheral T Cell Lymphomas
ALKETV6FGFR3ITKMYO1FNPM1S100A7SYKTBL1XR1THAP4TP63VAV1ALKARID1AASXL1ATMCDKN2A (P16INK4A)CTNNB1DNMT3AIDH2IRS4KIT (CD117)KMT2DKRASMAP2K1MSNNRASPLCG1PTENRGS7RHOASTAT3STAT5BTRRAPXPO1ZFHX3ZNF479
Precursor T Cell Lymphoblastic Lymphomas
ABL1JAK2NUP214PCM1SETCTNNB1FBXW7NRASWT1
T Cell Lymphomas
ATXN2LFGFR1JAK2
Other Lymphomas
ALKATXN2LBCL6BIRC3 (c-IAP2)CBFBCCND1CCND3CDK6CHIC2CLTCDEKDUSP22EIF4A1JAK2KMT2AMALT1MKL1MLF1MLLT10NFKB2NPM1PRDM16
Commercial Control Samples
ALKBAIAP2L1BRAFCCDC6CD74EGFR (ERBB1)EML4ERGETV6FGFR3KIF5BLMNAMETNCOA4NTRK1NTRK3PAX8PPARGRETROS1SEPT14SLC34A2SLC45A3TACC3TFGTMPRSS2TPM3
Checkpoint Molecules
Inhibitory on Tumor Cells​
CD200CD274 (PD-L1)CD274 (PD-L1)CD48CD80CD86ITGAVITGB3LGALS9MICAMICBPDCD1LG2TNFRSF14VSIR
Stimulatory on Tumor Cells​
CD40 (TNFRSF5)CD40LGCD48CD70CD86ICOSLGTNFRSF9TNFSF14TNFSF4 (OX40L)TNFSF9
Inhibitory on T Cells​
BTLACD160CD200R1CD244CD274 (PD-L1)CD274 (PD-L1)CD28CTLA4HAVCR2KLRC1LAG3LILRB1LILRB3PDCD1 (PD1)PDCD1 (PD1)VSIR
Stimulatory on T Cells​
CD244CD27 (TNFRSF7)CD28CD40 (TNFRSF5)CD40LGICOSTNFRSF14TNFRSF18TNFRSF4 (OX40)TNFRSF9TNFSF14TNFSF9
T Cell Receptor Genes​
CD247CD3DCD3ECD3GTRACTRGC2
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-HMR1
Major Histocompatibility Complex II Genes​
CD74HLA-DMAHLA-DMBHLA-DOAHLA-DOBHLA-DPA1HLA-DPB1HLA-DQA1HLA-DQA2HLA-DQB1HLA-DQB2HLA-DRAHLA-DRB1HLA-DRB5IFI30
Other Checkpoint Molecules​
ADORA2ABTNL2CD160CD276CD44CD52CD8AHHLA2IDO1 (IDO)IDO1 (IDO)IDO2KIR3DL1KLRD1LAIR1MS4A1NRP1TIGITTMIGD2TNFRSF25 (DR3)TNFRSF8TNFSF15VTCN1
Checkpoint Blockade Therapy Biomarkers
BTLACD274 (PD-L1)CD274 (PD-L1)CD80CD8ACSF2 (GM-CSF)CXCL11 (I-TAC, IP-9)HAVCR2HLA-DRAHLA-DRB1HLA-DRB5ICOSIFNGLAG3PDCD1 (PD1)PDCD1 (PD1)PDCD1LG2
Immuno Regulatory Gene Signature
ERBB2 (HER-2, NEU)FASIL5RA (CD125)INHBATNFRSF8TNFSF4 (OX40L)TNFSF9
Immuno Stimulatory Gene Signature
CD160CD19CD200CD27 (TNFRSF7)CD44CTLA4HLA-AIL12RB2IL17AKIT (CD117)TNFRSF17
Immuno Suppressive Gene Signature
CD274 (PD-L1)CD274 (PD-L1)CD276HAVCR2PDCD1LG2TGFB1
Upregulated in Cancer Vaccination Response
CCL5 (RANTES)CD3DCD86CD8ACXCL10 (INP10)CXCL9 (MIG)GBP1ICOSIRF1KLRD1PSMB9STAT1
Immune Cell Markers
CD8 T Cells​
CD8ACD8BFLT3LGGZMMPRF1
Th1 Cells​
CCL4 (MIP-1B)CD38CD70CSF2 (GM-CSF)CTLA4DPP4IFNGIL12RB2LTA (TNFB)STAT4TBX21
Th17 Cells​
IL17AIL17RARORC
Th2 Cells​
CXCR6GATA3IL26LAIR2MAFPMCHSMAD2 (MADH2)STAT6
Follicular Helper T Cells​
BCL6CXCL13MAFPDCD1 (PD1)PDCD1 (PD1)
Other T Helper Cell Markers​
ANP32BBATFCD28ICOSNUP107
Regulatory T Cells​
FOXP3
Gamma Delta T Cells​
CD160FEZ1TRGC1
Central Memory T Cells​
ATMDOCK9FYB1NEFLREPS1TXKUSP9Y
Effector Memory T Cells​
AKT3CCR2EWSR1IL15RALTKNFATC4 (NFAT3)
Other T Cell Markers​
CD2CD247CD3DCD3ECD3GCD6IL2RBTNFRSF25 (DR3)TRACTRGC2
Myeloid Derived Suppressor Cells​
TGFB1
Cytotoxic Lymphocytes​
CD3ECD3GCD8ACD8BEOMESGZMAGZMBIFNGKLRC1KLRD1NKG7TBX21
Natural Killer Cells​
BCL2CD160FOXJ1FUT5GTF3C1GZMBIL21RKIR3DL1MPPED1NCR1PLA2G6RRADZNF205
Activated Dendritic Cells​
CCL1 (I-309)EBI3LAMP3OAS3
Immature Dendritic Cells​
CD1ACD1BCD1EF13A1SYT17
Myeloid Dendritic Cells​
CD1ACD1BCD1E
Plasmacytoid Dendritic Cells​
IL3RA
Other Dendritic Cell Markers​
CCL13 (MCP-4)CCL17 (TARC)CCL22 (MDC)CD209HSD11B1
Macrophages​
APOECCL7 (MCP-3)CD68CHIT1CXCL5 (ENA-78, LIX)MARCOMSR1
Neutrophils​
CSF3R (GM-CSFR)FPR2MME
Eosinophils​
CCR3IL5RA (CD125)PTGDR2 (CRTH2, GPR44)SMPD3THBS1 (TSP-1)
Mast Cells​
CMA1CTSGKIT (CD117)MS4A2PRG2TPSAB1
B Cells​
BANK1BLKCD19CD79ACR2HLA-DOBHLA-DQA1MS4A1PAX5TNFRSF17
Antigen Presenting Cells​
CMKLR1
Regulatory T Cell Gene Signature
CD274 (PD-L1)CD274 (PD-L1)JAK1PDCD1LG2TIGITTNFRSF18TNFRSF4 (OX40)TNFRSF8TNFRSF9
T Cell Trafficking & Infiltration into Tumors
Stimulates T Cell Trafficking & Infiltration into Tumors​
CCL5 (RANTES)CX3CL1CXCL10 (INP10)CXCL9 (MIG)ITGB2SELL (LECAM-1)
Other T Cell Trafficking & Infiltration into Tumors Genes​
CCL17 (TARC)CCL4 (MIP-1B)CCR3CCR6CD274 (PD-L1)CD274 (PD-L1)CD44CSF2 (GM-CSF)CXCL11 (I-TAC, IP-9)CXCL13FOXP3IFNGITGA4 (CD49D)ITGB7LTA (TNFB)PDCD1 (PD1)PDCD1 (PD1)PDCD1LG2PTENTNFRSF25 (DR3)TNFSF14
T Cell Exhaustion
Upregulated in T Cell Exhaustion​
CCL5 (RANTES)CD200CD27 (TNFRSF7)CD69CTLA4CXCL10 (INP10)CXCL13GBP1HLA-DMAHLA-DQA1ICOSIFI16IFNGITGAVTAP1 (ABCB2)TIGITTNFRSF9
Downregulated in T Cell Exhaustion​
TNFRSF25 (DR3)
T Cell Exhaustion Transcriptional Nodes​
BATFTBX21
Responsiveness or Response Biomarkers
Enhanced Expression in Responsive Versus Nonresponsive Cancers​
APPCAPZBCCL4 (MIP-1B)CCL5 (RANTES)CD8ACSNK1ECTLA4CXCL10 (INP10)CXCL11 (I-TAC, IP-9)CXCL9 (MIG)EBI3EHD1GBA2GZMBHLA-DQA1IDO1 (IDO)IDO1 (IDO)IFNGINHBAIRF2NKG7ODF2PHKG2PPIFPRF1SERPINA3SHMT2SIGMAR1SMAD3 (MADH3)TIA1
Suppressed Expression in Responsive Versus Nonresponsive Cancers​
ACTG1BNIP3LCX3CL1FOXN3IFI27JAK1LTA4HNAIPOPTNPRRC2BPTENRBL2TXK
Differentially Expressed in Responsive Versus Nonresponsive Cancers​
ADAM28AKNAAOAHARHGAP9CACNA2D2CARD11CARD16CD109CLEC11ACORO1ACORO1BCXCR4FLT3FMNL1HIVEP1HIVEP2IFI44LIFITM1 (9-27)IGHA1IGHMIGSF6IKZF1ITPKALSM4LST1MAP3K14NFAM1NFKBIL1PLA2G2DPOU2AF1 (OCA-B)PTPRCAPSERPINB9SH3BP5SYTL1TMC8TNFRSF13BTNFRSF19ZFYVE9
Expression Correlates with Positive Objective Response Rates​
CD274 (PD-L1)CD274 (PD-L1)CD276CTLA4HAVCR2IDO1 (IDO)IDO1 (IDO)LAG3PDCD1LG2VTCN1
Upregulated during Treatment​
CD8ACTLA4CXCL10 (INP10)EOMESGZMAGZMBICOSIFNGPRF1
Regulated during Treatment​
IRF1
Pre-Treatment Response Prediction
Predicts Enhanced Response​
ADAM17 (CD156B)MYCRHOCTIMP1
Other Pre-Treatment Response Predictors​
CDK2CDKN2A (P16INK4A)LARGE1NAB2NRAS
Cancer Cell Killing
Inhibits Cancer Cell Killing​
BTLACD274 (PD-L1)CD274 (PD-L1)CD80HAVCR2IDO1 (IDO)IDO1 (IDO)IDO2LAG3MICAMICBPDCD1 (PD1)PDCD1 (PD1)TGFB1VSIRVTCN1
Stimulates Cancer Cell Killing​
IFNG
Antigen Processing & Presentation
Proteasome​
PSMB10PSMB9
Proteases​
IFI30
Endoplasmic Reticulum & Lysosomal Transport​
TAP1 (ABCB2)TAP2 (ABCB3)TAPBPL
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-HMR1
Major Histocompatibility Complex II Genes​
CD74HLA-DMAHLA-DQA1HLA-DRAHLA-DRB1HLA-DRB5IFI30
Immune Cell Receptors & Co-Receptors​
CD8ACD8BKIR3DL1KLRC1KLRD1
Stimulates Antigen Presentation​
CD40 (TNFRSF5)CD40LG
Interferon Gamma Response
Cytokines & Chemokines​
CCL5 (RANTES)IL15RASTAT1
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-H
Major Histocompatibility Complex II Genes​
HLA-DMAHLA-DQA1HLA-DRAHLA-DRB1HLA-DRB5IFI30
RNA Degradation​
OAS3
Transcription Factors​
IRF1IRF2
Other Interferon Gamma Response Genes​
CD44GBP1
Cytosolic DNA-Sensing Pathway
Cytokines & Interferons​
CCL4 (MIP-1B)CCL5 (RANTES)CXCL10 (INP10)
Expression Altered due to Genetic Alterations
BCL10BCL2BCL3BCL6BCL9CCND1CCND2CCND3CD44CDK6ERVW-1FCGR2BFCRL4FOXP1GPR34IRF4KDSRMALT1MTCP1MUC1 (mucin)MYCNBEAP1NFKB2PAX5PRDM16
AIDS-Related Lymphomas
EZH2
B Cell Lymphomas
ARID1AATMB2MBCL2BCORBRAFCD79BCDKN2A (P16INK4A)CREBBP (CBP)CTNNB1CXCR4DNMT3AEZH2JAK3KIT (CD117)KMT2DMAP2K1MYD88PIK3CA (p110-alpha)PPM1DPTENRHOASTAT3
Small Lymphocytic Lymphomas
ALKAPCARID1AASXL1ATMBCL2BCORBRAFBTKCD79BCDKN2A (P16INK4A)CNOT3CREBBP (CBP)CXCR4DNMT3AFBXW7GNASIRS4JAK1JAK3KIT (CD117)KMT2DKRASMAP2K1MED12MSNMYCMYD88NCOR1NFKBIENOTCH2NRASPAX5PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PLCG1POT1PPM1DPTENRGS7SF3B1STAT5BSTAT6TERTTRRAPXPO1ZFHX3ZMYM3ZNF479
Cutaneous T Cell Lymphomas
KRASPTEN
Diffuse Red Pulp Small B Cell Lymphomas
MYD88NOTCH2
Enteropathy-Type T Cell Lymphomas
STAT5B
Gamma-Delta T Cell Lymphomas
STAT3STAT5B
Hepatosplenic T Cell Lymphomas
STAT3STAT5B
Lymphoplasmacytic Lymphomas
ARID1ABTKCD79BCXCR4DNMT3AMYD88
Marginal Zone Lymphomas
AMER1ARID1AASXL1ATMBRAFCD79BCREBBP (CBP)CXCR4DNMT3AEZH2FBXW7GNASJAK3KIT (CD117)KMT2DMAP2K1MYD88NFKBIENOTCH2PIK3R1 (p85-ALPHA)RHOASRSF2TRRAPXPO1
Mycosis Fungoides (Sezary Syndrome)
AMER1ARID1AATMBCORCDKN2A (P16INK4A)DNMT3AJAK1JAK3KMT2DKRASNCOR1NRASPIK3CA (p110-alpha)PLCG1POT1PTENSTAT3STAT5B
NK-T Cell Lymphomas
ALKAMER1APCARID1AASXL1ATMB2MBCORBRAFCTNNB1DNMT3AEZH2FBXW7HLA-AJAK1JAK3KIT (CD117)KMT2DKRASMED12NCOR1NOTCH2NRASPOT1RGS7RHOASMOSTAT3STAT5BWT1XPO1ZFHX3
Primary Central Nervous System Lymphomas
B2MBCL2CD79BCDKN2A (P16INK4A)CXCR4DNMT3AHLA-AJAK3KIT (CD117)KRASMYD88NOTCH2POT1STAT3STAT5BTERTTRRAPWT1
Primary Effusion Lymphomas
CDKN2A (P16INK4A)PTEN

Product Resources

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Resources

Safety Data Sheets (1)
Safety Data Sheets
Kit Handbooks (1)
QIAseq RNA Fusion XP Panel Handbook
PDF (3MB)
Template Files (1)
QIAseq RNA Fusion XP All-in-One Tool
SOFTWARE (884KB)
Certificates of Analysis (1)
Certificates of Analysis
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