Target List
Oncogenes
ABL1, AKT1, AKT2, ALK, AR, BCL2, BRAF, CARD11, CBL, CDK4, CRKL, CRLF2 (TSLPR), CSF1R, CTNNB1, DNMT3A, EGFR (ERBB1), ERBB2 (HER-2, NEU), EZH2, FGFR2, FGFR3, FLT3, FOXL2, GATA2, GNA11, GNAQ, GNAS, H3-3A, H3C2, HRAS, IDH1, IDH2, IKBKE, JAK1, JAK2, JAK3, KIT (CD117), KRAS, MAP2K1, MED12, MET, MPL, MYD88, NFE2L2, NRAS, PDGFRA, PIK3CA (p110-alpha), PPP2R1A, PTPN11, REL, RET, SF3B1, SMO, SPOP, SRC, TSHR, U2AF1
Tumor Suppressor Genes
ACVR1B, AMER1, APC, ARID1A, ARID1B, ARID2, ARID5B, ASXL1, ASXL2, ATM, ATRX, AXIN1, B2M, BAP1, BARD1, BCOR, BRCA1, BRCA2, CDC73, CDH1 (E-Cadherin), CDKN2A (P16INK4A), CEBPA, CIC, CREBBP (CBP), CYLD, DAXX, EP300, FAT1, FBXW7, FLCN, FOXP1, FUBP1, GATA1, GATA3, HNF1A, KDM5C, KDM6A, KMT2C, KMT2D, MAP3K1 (MEKK1), MEN1, MLH1, NF1, NF2, NOTCH1, NOTCH2, NPM1, PAX5, PHF6, PIK3R1 (p85-ALPHA), PRDM1, PTCH1, PTEN, RB1, RNF43, RUNX1 (AML1), SMAD2 (MADH2), SMAD4 (MADH4), SMARCA4, SMARCB1, SOCS1, SOX9, STAG2, STK11 (LKB1), TET2, TNFAIP3, TP53 (p53), TSC1, TSC2, VHL, WT1, ZFHX3
Angiogenesis
AKT1, AKT2, AKT3, CTNNB1, ERBB2 (HER-2, NEU), FGFR2, FLT1 (VEGFR1), FLT4 (VEGFR2), GATA2, KDR (VEGFR3), NF1, NOTCH1, PIK3CA (p110-alpha), PTEN, PTGS2 (COX2), RUNX1 (AML1), TNFAIP3, VEGFA, VEGFD (VEGFD), VHL
Apoptosis
ABL1, ABL2 (ARG), AKT1, AKT2, AKT3, APC, ARAF, AXIN1, BCL2, BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL6, BRAF, CASP8 (FLICE), CBL, CDKN1A (p21CIP1, WAF1), CDKN2A (P16INK4A), CTNNA1, CTNNB1, CYLD, DAXX, FAS, FLT3, FOXL2, GATA1, HGF, HRAS, MAP2K4 (MKK4, JNKK1), MCL1, MDM4, MYCN, NF1, NPM1, PIM1, PRKCI, PTEN, RAD21, RAD50, RAD51, RAF1, RB1, REL, SOX9, STK11 (LKB1), TNF, TNFAIP3, TP73, VHL, WT1
Cell Adhesion Molecules
ABL1, ABL2 (ARG), APC, CDH1 (E-Cadherin), CTNNB1, DDR2, EGFR (ERBB1), EPCAM, ERBB2 (HER-2, NEU), FAT1, GATA1, JAK2, KDR (VEGFR3), NF1, NF2, NOTCH1, PDGFRA, PTEN, PTGS2 (COX2), PTPN11, RAC1, RET, RHOA, SRC, TSC1
Cell Cycle
ABL1, ABL2 (ARG), AKT1, AKT2, AKT3, APC, ATR, BLM, BRD4, CCND1, CCND2, CCND3, CCNE1, CDC27, CDC73, CDK12, CDK4, CDK6, CDK8, CDKN1A (p21CIP1, WAF1), CDKN1B (P27KIP1), CDKN2A (P16INK4A), CDKN2B (p15INK4b), CDKN2C (p18-INK4C), CHEK1, CHEK2 (RAD53), CREBBP (CBP), CUX1, CYLD, FBXW7, FGFR2, HRAS, MYC, NPM1, PIM1, PTEN, PTPRD, RAD21, RAD50, RAD51, RB1, RHEB, RHOA, SMARCA4, SMARCB1, SMC1A, SMC3, SOX2, SOX9, STAG2, STK11 (LKB1), TNFAIP3, TP53 (p53), TP53BP1, TSC1, WEE1, XPO1, ZFHX3
DNA Damage & Repair
ABL1, ABL2 (ARG), APC, ATM, ATR, ATRX, AXIN2, BRCA1, BRCA2, BRIP1, CDKN1A (p21CIP1, WAF1), CHEK1, CHEK2 (RAD53), EP300, EPCAM, ERCC1, ERCC2 (XPD), ERCC3 (XPB), ERCC4, ERCC5, EXO1, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, GADD45A, HERC1, HMGB1, HMGN1, LIG1, LIG3, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MEN1, MLH1, MLH3, MRE11, MSH2, MSH3, MSH4, MSH5, MSH6, MTOR, MUTYH, NBN, NPM1, PALB2, PARP1 (ADPRT1), PCNA, PIK3C2B, PMS1, PMS2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE4, PRKCG, PRKCZ, PRKDC, RAD17, RAD18, RAD21, RAD50, RAD51, RAD51C, RFC1, RFC2, RFC3, RFC4, RFC5, RNASEH2A, RPA1, RPA2, RPA3, RPA4, SETD2, SIRT1, SMC1A, SMC3, SSBP1, STK11 (LKB1), TDG, TP53 (p53), TP53BP1, TP73, TREX1, TRRAP, XRCC5
Epigenetics
ARID1A, ARID1B, ARID2, ARID5B, ASXL1, ASXL2, ATRX, AURKA, AURKB, BCOR, BCORL1, BRD4, CHD4, CTCF, DICER1, DNMT3A, DOT1L, EED, EZH2, FOXA1, H3-3A, H3C2, IKZF1, KAT6A, KDM5A, KDM5C, KDM6A, KMT2A, KMT2C, KMT2D, NCOR1, NSD1, PBRM1, PHF6, PRDM1, RARA, RUNX1T1, SMARCA4, SMARCB1, SPOP, SUZ12, TET2, TRRAP
Hypoxia Signaling
CREBBP (CBP), EP300, NF1, PDK1, SMAD4 (MADH4), VHL
Immune Response
ALK, B2M, BTK, CARD11, CD274 (PD-L1), CD274 (PD-L1), CD276, CD79A, CD79B, CREBBP (CBP), CRLF2 (TSLPR), CYLD, EP300, FAM46C, IL7R, IRF4, JAK1, JAK2, JAK3, MAP2K1, MAP2K2 (MEK2), MAP3K1 (MEKK1), MCL1, MYD88, NFKBIA (IκBα, MAD3), PAX5, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PTEN, PTPN11, REL, TNFAIP3, TNFRSF14, TP53 (p53)
Inflammatory Response
CEBPA, CSF1R, JAK2, MYD88, PTGS2 (COX2), REL
Metabolism
AKT1, AKT2, AKT3, ASXL2, FH, FLCN, IDH1, IDH2, MTOR, PDK1, PTGS2 (COX2), RICTOR, RPTOR, SDHA, SDHB, SDHC, SDHD, TNF, TSC2
RNA Splicing
DDX3X, QKI, RBM10, SF3B1, SMC1A, U2AF1
Signal Transduction
ACVR1B, AKT1, AKT2, AKT3, ALK, AMER1, APC, AXIN1, AXL, CBFB, CDKN1A (p21CIP1, WAF1), CNKSR1, CSF1R, CYLD, DDR2, DNER, EGFR (ERBB1), EPHA3, EPHA5, EPHA7, EPHB1, ERBB2 (HER-2, NEU), ERBB3, ERBB4, ERRFI1, EWSR1, FBXW7, FGF19, FGF3, FGF4, FGFBP1, FGFR1, FGFR2, FGFR3, FGFR4, FLT1 (VEGFR1), FLT3, FLT4 (VEGFR2), GABRA6, GATA2, GLI1, GNA11, GNA13, GNAQ, GNAS, GRIN2A, GSK3B, HGF, HNF1A, IGF1R, IGF2, IGF2R, IKBKE, INPP4B, IRF6, IRS2, JAK1, JAK2, JAK3, KDR (VEGFR3), KIT (CD117), KRAS, LMO1, LPAR2, MAP2K1, MAP2K2 (MEK2), MAP3K1 (MEKK1), MED12, MET, NF1, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NRAS, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PIK3CA (p110-alpha), PIK3CB, PIK3CG, PIK3R1 (p85-ALPHA), PIK3R2 (p85-BETA), PLCG2, PPP2R1A, PRKAR1A, PRKCI, PTCH1, PTEN, PTPN11, RAF1, RASA1, RET, RIT1, RNF43, ROS1, SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SMO, SOCS1, SOS1, SOX17, SOX2, SPEN, SRC, STAT3, SUFU, SYK, TCF7L2, TGFBR2, TNF, TNKS (TIN1), TRRAP, TSC2, TSHR
Transcription Factors
AR, CEBPA, CIC, CUX1, ERG, ESR1 (ERα), ETV6, FBXW7, FOXA1, FOXL2, FOXP1, FUBP1, GATA1, GATA2, GATA3, GATA4, GATA6, GLI1, HNF1A, IRF4, IRF6, JUN, KEAP1, LZTR1, MEF2B, MEN1, MITF, MYB, MYC, MYCL, MYCN, MYOCD, NFE2L2, NKX2-1, PAX5, RB1, RUNX1 (AML1), SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SOX10, SOX17, SOX2, SOX9, TBX3, TCF7L2, TP53 (p53), TP73, WT1, ZFHX3, ZNF217
Ubiquitination
ASXL2, BAP1, BCOR, CDC27, CUL3, CUL4B, DAXX, MDM2, PRKN, RNF43
Unfolded Protein Response
HSP90AA1, NFE2L2, NPM1
Major Histocompatibility Complex Genes
B2M, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, MR1
Antigen Presentation
ABCB9, ACE2, CALR, CANX, CTSB, CTSL, CTSS, ERAP1, ERAP2, IDE, IFI30, LGMN, LNPEP, NPEPPS, NRD1, PDIA3, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB10, PSMB11, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9, PSMC1, PSMC2, PSMC3, PSMC4, PSMC5, PSMC6, PSMD1, PSMD10, PSMD11, PSMD12, PSMD13, PSMD14, PSMD2, PSMD3, PSMD4, PSMD5, PSMD6, PSMD7, PSMD8, PSMD9, PSME1, PSME2, PSME3, PSME4, PSMF1, PSMG1, PSMG2, PSMG3, PSMG4, TAP1 (ABCB2), TAP2 (ABCB3), TAPBP, TAPBPL, TOP1, TPP2
Immune Checkpoint Molecules
VSIR, CD200, CD274 (PD-L1), CD274 (PD-L1), CD276, CD40 (TNFRSF5), CD40LG, CD48, CD70, CD80, CD86, ICOSLG, ITGAV, ITGB3, LGALS9, MICA, MICB, PDCD1LG2, TNFRSF14, TNFRSF9, TNFSF14, TNFSF18, TNFSF4 (OX40L), TNFSF9, VTCN1
Other Cancer-Related Genes
ALPK2, COL5A1, DIS3, DMD, FKBP9, KEL, LRP1B, MORC4, MUC17, TCP11L2, TERC, TERT, TOP1