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GeneGlobe ID: JHS-3001Z | Cat. No.: | QIAseq RNA Fusion XP Panels

QIAseq RNA Fusion XP Oncology Research Panel

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Product Specification

Kit containing ALL reagents (except indexes) for fusion and gene expression profiling by digital RNAseq

Target List

Covers specific sides of specific exons of the targeted genes based on the Human GRCh38 genome build.Analyzes the expression of the targeted genes.Covers specific hotspots of the targeted genes based on the Human GRCh38 genome build.

Bone Cancer
Askins Tumors
ERGEWSR1FLI1FUS
Ewing's Sarcomas
ERGETV1ETV4EWSR1FEVFLI1FUSNFATC2SMARCA5
Giant Cell Tumors
EWSR1FLI1
Mesenchymal Chondrosarcomas
CDX1HEY1IRF2BP2NCOA2
Myxoid Chondrosarcomas
EWSR1NR4A3TAF15TCF12TFG
Brain Cancer
Gliomas
AKT2BRAFCLCN6FAM131BFGFR1FGFR3FIP1L1GNAI1GOPCMKRN1MYBPDGFRAPRKCBRAF1RNF130ROS1SRGAP3TACC1TACC3
Neuroblastomas
EWSR1FLI1
Pilocytic Astrocytomas
CLCN6FAM131BGNAI1MKRN1RNF130SRGAP3TACC1
Other Brain Cancers
EWSR1FLI1NAB2PDGFRAPRKCASTAT6
Breast Cancer
Carcinomas
AKT2BRD3DAZLETV6FGFR1JAK1KITMAST1MAST2NTRK3PIK3CARAF1TBL1XR1ZC3H7BZNF703
Ductal Carcinomas
DAZLETV6NTRK3
Other Breast Cancers
AKT3ESR1NOTCH2
Colorectal Cancer
Adenocarcinomas
ETV6INSRNTRK1NTRK3TCF7L2TPM3VTI1A
Kidney Cancer
Carcinomas
ALKASPSCR1PRCCTFE3VCL
Clear Cell Sarcomas
TERT
Mesoblastic Nephromas
ETV6NTRK3
Renal Cell Carcinomas
TFEBVCL
Leukemia
Acute Leukemia of Ambiguous Lineage
ABL1AFF1BCRCT45A2ETV6EWSR1GPHNKMT2AMLLT10MN1NUP214PBX1SETTCF3ZNF384
Acute Lymphoblastic Leukemia (ALL)
ABL1ABL2ACTN4AFDNAFF1AFF3AFF4AGGF1ANLNASNSATF7IPAUTS2BCL11BBCL9BCRBTBD18CASC5CREBBPCRLF2CSF1RDDX3XEBF1ELLELNEML1EP300EPOREPS15ESRRBETV6EWSR1FGFR1FGFR1OPFLT3FOXO4FOXP1FRYLGAS7GPHNHLFHNRNPUL1IL2RBINPP5DJAK2KMT2AKMT2ELNP1MAML2MEF2DMLLT1MLLT10MLLT3MN1MNX1MYBMYCNCOA2NOTCH1NUP214NUP98P2RY8PAG1PAX5PBX1PCM1PDGFRBPICALMPMLPRDM16RAP1GDS1RARARCSD1RUNX1SALL2SETSFPQSPI1SSBP2STILSTMN1TAF15TAL1TCF3TCF7TET1TSLPTYK2USP9XZBTB16ZCCHC7ZMIZ1ZMYM2ZNF384ZNF521
Acute Myeloid Leukemia (AML)
ABI1ABI2ABL1AFDNAFF1AFF4ALKANLNARHGAP26ARHGEF12BCORBCRCASC5CBFA2T3CBFBCBLCCDC88CCEP170BCHD1CHIC2CREBBPDAB2IPDDX10DEKDHHDIAPH2ELLEP300EPS15ERGETV6FGFR1FIP1L1FLNAFNBP1FOXO3FOXO4FRYLFUSGAS7GATA1GLIS2GPHNHAUS1HOXA9HOXC11HOXC13HOXD13IRF2BP2JAK2KAT6AKDM5AKIAA1524KITKMT2ALASP1LNP1LPPLYNMAML2MECOMMKL1MLF1MLLT1MLLT10MLLT11MLLT3MLLT6MN1MNX1MYBMYH11MYO1FNCKIPSDNCOA2NF1NPM1NSD1NTRK3NUMA1NUP214NUP98PAN3PBX1PCM1PDGFRAPDGFRBPDS5APHF23PICALMPMLPRDM16PRRX1PSIP1PSMA2PTPRRRANBP2RARARBM15RHEBL1RPL22RPN1RUNX1RUNX1T1SARNPSEPT2SEPT5SEPT6SEPT9SETSH3GL1SORBS2STAT5BTAF15TCF3TET1TFGTOP1TOP3ATRIP11TYK2UBA2USP42WHSC1L1WTIPZBTB16ZFYVE19ZNF384
Acute Myelomonocytic Leukemia (AMML)
FLNAHOXD13NUP98
B-Cell Acute Lymphoblastic Leukemia (B-ALL)
ABL1ACTN4AFF1AFF3AFF4ATF7IPBCRBTBD18CRLF2EPS15ERGESRRBETV6EWSR1FUSGAS7JAK2KMT2AMAPRE1MLLT1NUP214P2RY8PAX5PBX1PCM1RUNX1SETSSBP2TCF3USP9XZNF384ZNF521
Blast Phase Chronic Myeloid Leukemia
ABL1BCRETV6JAK2
Chronic Eosinophilic Leukemia
ACSL6TNIP1
Chronic Lymphocytic Leukemia (CLL)
MYCNOTCH1
Chronic Myeloid Leukemia (CML)
ABL1BCRCCDC88CETV6HOXA11HOXA13JAK2MECOMMN1NDE1NUP98PCM1PDGFRBRUNX1
Chronic Myelomonocytic Leukemia (CMML)
CREBBPELLETV6KMT2AMN1
Myelodysplastic Syndromes (MDS)
ABL1ACTN4ALKCASC5CREBBPDEKERGETV6FRYLFUSHOXD13JAK2KMT2ALNP1MAML2MECOMMLF1MN1MNX1NDE1NPM1NUP214NUP98PCM1PDGFRBPRDM16PTPRRRANBP2RUNX1RUNX1T1TOP1
Myeloproliferative Neoplasms
ABL1ACSL6BCRETV6FGFR1FGFR1OPFIP1L1FLT3HOXA9HOXD13JAK2LYNMECOMMLF1MN1NPM1NUP98PDGFRBPRKG2PSIP1RARARUNX1TNIP1ZMYM2
T-Cell Acute Lymphoblastic Leukemia (T-ALL)
ABL1AFDNAGGF1ASNSBCL11BBCRCASC5DDX3XETV6JAK2KMT2AKMT2EMLLT1MLLT10NOTCH1NUP214PBX1RUNX1SALL2SETSPI1STILSTMN1TAL1TCF3TCF7
Other Leukemias
BCL11BIKZF2IKZF3IRF2BP2MYCNPM1PDCD1LG2SETD2TYK2
Liver Cancer
Cholangiocarcinomas
CCDC6FGFR2TACC3
Hepatocellular Carcinomas
PKN1
Lung Cancer
Acinar Adenocarcinomas
ALKCD74EML4HIP1KIF5BROS1SDC4
Adenocarcinomas
ALKBAIAP2L1BCL11ABRAFCCDC6CD74CUX1EML4ERBB2ERBB4EZRFGFR2FGFR3GCC2GOPCHIP1HLA-DRB1KIAA1217KIF5BKLC1LRIG3METMPRIPNCOA4NRG1NTRK1NTRK2PBX1PRKCBRETROS1SDC4SLC34A2SND1STARD3NLSTRNTACC3TCF3TFGTPM3TPRTRIM24TRIM33
Bronchioloalveolar Adenocarcinomas
ALKEML4KLC1PBX1ROS1SDC4TCF3
Inflammatory Myofibroblastic Tumors
ALKCD74EML4EZRGOPCLRIG3PPFIBP1ROS1SDC4SLC34A2TPM3
Invasive Mucinous Adenocarcinomas
ALKCD74EML4NRG1SLC3A2
Mixed Adenosquamous Carcinomas
ALKEML4KIF5BRET
Mucoepidermoid Carcinomas
ALKCRTC1EML4MAML2
Non-Small Cell Carcinomas
ALKBCL11ACCDC6CD74CUX1EGFREML4EZRGCC2GOPCHIP1KIAA1217KIF5BKLC1LRIG3NCOA4RETROS1SDC4SLC34A2STRNTFGTPM3TPRTRIM33
Non-Small Cell Lung Cancers (NSCLC)
ALKBAG4BAIAP2L1BCL11ACCDC6CD74CLIP4CUX1DNAH5EGFREML4ETV6EZRFERFGFR1FGFR3GCC2GLRX5GOPCHIP1HLA-DRB1IRF2BP2KIAA1217KIF5BKLC1LRIG3MAN2A1METMPRIPNCOA4NRG1NTRK1NTRK3RAD51RETROS1RUNX1SDC4SLC34A2SLC3A2SQSTM1STRNTACC3TFGTPM3TPRTRA2BTRIM33VSNL1
Squamous Cell Carcinomas (SCC)
ALKBAIAP2L1CD74EML4FGFR2FGFR3FGRHIP1KIF5BKITNRG1PKN1PRKCAPRKCBRETTACC3
Other Carcinomas
ALKBRD4EML4NUTM1
Other Lung Cancers
ARL17ABAG4BAIAP2L1CCDC6CD74CUX1EZRFGFR1FGFR3GOPCIRF2BP2KANSL1KIAA1217KIF5BLRIG3MPRIPNCOA4NRG1NTRK1NUTM1PTPRKRETROS1RSPO3SDC4SLC34A2SLC3A2SQSTM1TACC3TPM3TPRTRIM33WHSC1L1
Lymphoma
Acute Lymphoblastic Lymphomas
BCL11BCREBBPEBF1KMT2AMLLT10MYCP2RY8PRDM16STIL
Anaplastic Large Cell Lymphomas
ADGRG7ALKATICCLTCMSNMYCNPM1TFGTPM3TPM4
Angioimmunoblastic T Cell Lymphomas
CD28CTLA4FIP1L1PDGFRA
Burkitt Lymphomas
BCL6MYCPBX1TCF3
Diffuse Large B Cell Lymphomas (DLBCL)
ALKBCL11ABCL6CCND3CIITACLTCIGLL5LPPMAPK13MYCNPM1PIM1RELSQSTM1TBL1XR1TOMM40TP63ZCCHC7
Follicular Lymphomas
AFF3BCL2BCL6CIITAMYCTBL1XR1TP63
Granulocytic Sarcomas
RUNX1RUNX1T1
Hodgkin Lymphomas
ALKCIITAJAK2NPM1SEC31A
Inflammatory Myofibroblastic Tumors
ALKCARSDCTN1
Lymphoblastic Lymphomas
BCRCRLF2EPORETV6FGFR1NOTCH1PBX1PDGFRBRARATERTZCCHC7
Lymphoblastic T Cell Lymphomas
BCRETV6FGFR1FIP1L1LYNPDGFRA
Mantle Cell Lymphomas
CCND3MYC
Mediastinal Large B Cell Lymphomas (MLBL)
CIITAPDCD1LG2
Mediastinal Large B-Cell Lymphomas
CIITAPDCD1LG2
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas
BCL6BIRC3CCND3MALT1MYC
Peripheral T Cell Lymphomas
ALKETV6FGFR3IKZF2ITKMYO1FNPM1S100A7SYKTBL1XR1THAP4TP63VAV1
Precursor T Cell Lymphoblastic Lymphomas
ABL1JAK2NUP214PCM1SET
T Cell Lymphomas
ATXN2LBCL11BFGFR1IKZF2JAK2
Other Lymphomas
ALKATXN2LBCL6BIRC3CBFBCCND1CCND3CDK6CHIC2CLTCDEKDUSP22EIF4A1JAK2KMT2AMALT1MKL1MLF1MLLT10MYCNFKB2NPM1PICALMPRDM16
Myelodysplastic Syndromes (MDS)
ABL1ACTN4ALKCASC5CREBBPDEKDIAPH2ERGETV6FGFR1FRYLFUSGOT1HOXA11HOXA13HOXD13JAK2KMT2ALNP1MAML2MECOMMLF1MN1MNX1MYH11NDE1NPM1NUP214NUP98PAN3PCM1PDGFRBPRDM16PSMA2PTPRRRANBP2RUNX1RUNX1T1SEPT9SYKTOP1ZMYM2
Myeloproliferative Neoplasms
ABL1ACSL6BCRCNTRLETV6FGFR1FGFR1OPFIP1L1FLT3FOXP1HOXA9HOXD13JAK2KANK1LYNMECOMMLF1MN1NPM1NUP98PCM1PDGFRAPDGFRBPRKG2PSIP1RARARUNX1TNIP1
Ovarian Cancer
Carcinomas
ESRRA
Serous Cyst Adenocarcinomas
AKT2AXLFGRINSRJAK1
Pancreatic Cancer
Acinar Cell Carcinomas
GATMHACL1HERPUD1SND1ZSCAN30
Adenocarcinomas
ACSL3ACVR2AAKT3BRAFCANT1DDX5ELK4ERGESRP1ETV1ETV4ETV5HNRNPA2B1KLK2KRASNDRG1PIK3CARAF1SLC45A3TBL1XR1TMPRSS2UBE2L3
Carcinomas
BRAFRAF1
Prostate Cancer
Adenocarcinomas
ACSL3ACVR2AAKT3BRAFCANT1DDX5ELK4ERGESRP1ETV1ETV4ETV5HNRNPA2B1KLK2KRASNDRG1PIK3CARAF1SLC45A3TBL1XR1TMPRSS2UBE2L3
Glandular Intraepithelial Neoplasia
ERGTMPRSS2
Other Carcinomas
ERGETV1TMPRSS2
Salivary Gland Cancer
Adenomas
FGFR1PLAG1
Mucoepidermoid Carcinomas
CRTC1MAML2
Warthin Tumors
CRTC1MAML2
Other Carcinomas
ETV6NTRK3
Other Salivary Gland Cancers
MYB
Sarcoma
Alveolar Soft Part Sarcomas
ASPSCR1TFE3
Angiosarcomas & Epitheliod Haemangioendotheliomas
CAMTA1CEP85LCICLEUTXROS1TFE3YAP1
Askins Tumors
ERGEWSR1FLI1FUS
Chondrosarcomas
ACVR2ACDX1EWSR1FN1HEY1IRF2BP2NCOA2NR4A3TAF15TCF12TFG
Clear Cell Sarcomas
ATF1CREB1EWSR1FLI1NUTM2BYWHAE
Congenital (Infantile) Fibrosarcomas
ETV6METNTRK3TFG
Dermatofibrosarcoma Protuberans
COL1A1PDGFB
Dermatofibrosarcomas Protuberans
COL1A1PDGFB
Desmoplastic Small Round Cell Tumors
ERGEWSR1FLI1PATZ1WT1
Endometrial Stromal Sarcomas
ALKBCORCXorf67EPC1FN1JAZF1MBTD1MEAF6NUTM2ANUTM2BPHF1SUZ12YWHAEZC3H7B
Epithelioid Sarcomas
CREB3L1CREB3L2EWSR1FUSKLF17SS18SSX1
Ewing's Sarcomas
CICERGETV1ETV4EWSR1FEVFLI1FOXO4FUSNFATC2SMARCA5SP3
Fibrosarcomas
BRAFCOL1A1CREB3L1CREB3L2EWSR1FUSLMNANTRK1PDGFBTOM1L2
Leiomyosarcomas
EWSR1HMGA2PBX3WT1
Liposarcomas
DDIT3EWSR1FUSHMGA2LGR5NUP107TERT
Myofibroblastic Sarcomas
ALKLMNANTRK1RELAROS1SRFTFGTPM3YWHAE
Myxofibrosarcomas
CREB3L1CREB3L2FUS
Myxoid Chondrosarcomas
NR4A3TAF15
Perivascular Epithelioid Cell Tumors (PEComa)
DVL2SFPQTFE3
Pleomorphic Sarcomas (Malignant Fibrous Histiocytoma)
CITED2MED12PRDM10
Rhabdoid Tumors
NCOA4RET
Rhabdomyosarcomas
CITED2EWSR1FLI1FOXO1NCOA1NCOA2PAX3PAX7SRFTEAD1VGLL2
Small Round Cell Tumors
ERGETV1EWSR1FEVFLI1FOXO1PAX3
Solitary Fibrous Tumors
NAB2STAT6
Synovial Sarcomas
COL6A3CSF1S100A10SS18SS18L1SSX1SSX2SSX2BSSX4B
Undifferentiated; Unclassified or Other Sarcomas
ATF1BCORBRD4CCNB3CREMERGETV4EWSR1FGF1FGFR1FLI1FN1FOXO1FUSGLI1JAZF1MAML3MKL2NPM1NUTM1PAX3PLAG1POU5F1RUNX1RUNX1T1SUZ12USP6
Skin Cancer
Adnexal Tumors; Hidradenomas
CRTC1MAML2
Atypical Spitzoid Tumors
ALKTPM3
Benign Melanocytic Nevus
ALKBRAFCEP89ERC1FCHSD1GOLGA5KIF5BLSM14AMYO5APPFIBP1PWWP2ARETROS1TPM3
Melanomas
AGKATF1BRAFCREB1EWSR1FCHSD1FGRPAPSS1TRIM24
Spitzoid Melanomas
CEP89LSM14AMYO5APPFIBP1PWWP2A
Soft Tissue Cancer
Clear Cell Sarcomas
ATF1EWSR1
Congenital (Infantile) Fibrosarcomas
ETV6NTRK3
Desmoplastic Small Round Cell Tumors
ERGEWSR1SSX1
Endometrial Stromal Sarcomas
ALKFN1
Epithelioid Sarcomas
SS18
Inflammatory Myofibroblastic Tumors
ALKATICCARSCLTCDCTN1PPFIBP1RANBP2SEC31ATPM3TPM4
Leiomyosarcomas
EWSR1WT1
Liposarcomas; Myxoid-Round Cell
DDIT3EWSR1
Liposarcomas; Pleomorphic
DDIT3FUS
Rhabdoid Tumors
NCOA4RET
Rhabdomyosarcomas
FOXO1PAX3PAX7
Sarcomas
ETV4EWSR1
Small Round Cell Tumors
ETV1EWSR1FEVFLI1
Solitary Fibrous Tumors
NAB2STAT6
Synovial Sarcomas
SS18SSX2SSX2B
Other Fibrosarcomas
COL1A1PDGFB
Stomach Cancer
Adenocarcinomas
AKT1ERBB2INSR
Thyroid Cancer
Adenoma-Nodule-Goitre
CCDC6NCOA4PAX8PPARGPRKAR1ARET
Anaplastic Carcinomas
ALKCCDC6NCOA4RETSTRN
Follicular Carcinomas
PAX8PPARG
Hurthle Cell Carcinomas
CCDC6NCOA4RET
Mucoepidermoid Carcinomas
CRTC1MAML2
Papillary Carcinomas
AGKAKAP9ALKBRAFCCDC6EML4ERC1ETV6GOLGA5HOOK3KTN1NCOA4NTRK1NTRK3PAX8PCM1PPARGPRKAR1ARETSTRNTFGTPM3TRIM24TRIM27TRIM33
Urinary Tract Cancer
Endometrial Carcinomas
INSRPIK3CA
Transitional Cell Carcinomas
BAIAP2L1FGFR3TACC3
Uterine Cancer
Endometrial Carcinomas
INSRPIK3CA
Other Hematological Malignancies
Eosinophilia
ETV6FOXP1LYNPDGFRA
Langerhans Cell Histiocytosis
NTRK3PLEKHA6
Plasma Cell Myelomas
ABL1BCR
Polycythemia Vera
GTF2H3
Severe Thrombocythemia
KANK1PDGFRB
Other Myeloid Neoplasms
KLF2PTK2BSEMA6A
Other Solid Tumors
Midline Carcinomas
BRD3BRD4NUTM1WHSC1L1
Squamous Cell Carcinomas (SCC)
MAST2
Other Solid Tumors
ARHGAP26BRD3INSRMAST2MSMBMUSKNUMBLNUTM1PDGFRBRSPO2THADA
Other Cancers
Midline Carcinomas
BRD3BRD4NUTM1WHSC1L1
Squamous Cell Carcinomas (SCC)
MAST2
Other Cancers
JAK3
Commercial Control Samples
ALKBAIAP2L1BRAFCCDC6CD74EGFREML4ERGETV6FGFR3KIF5BLMNAMETNCOA4NTRK1NTRK3PAX8PPARGRETROS1SEPT14SLC34A2SLC45A3TACC3TFGTMPRSS2TPM3
Checkpoint Molecules
Inhibitory on Tumor Cells
CD200CD274CD274CD48CD80CD86ITGAVITGB3LGALS9MICAMICBPDCD1LG2TNFRSF14VSIR
Stimulatory on Tumor Cells
CD40CD40LGCD48CD70CD86ICOSLGTNFRSF9TNFSF14TNFSF4TNFSF9
Inhibitory on T Cells
BTLACD160CD200R1CD244CD274CD274CD28CTLA4HAVCR2KLRC1LAG3LILRB1LILRB3PDCD1PDCD1VSIR
Stimulatory on T Cells
CD244CD27CD28CD40CD40LGICOSTNFRSF14TNFRSF18TNFRSF4TNFRSF9TNFSF14TNFSF9
T Cell Receptor Genes
CD247CD3DCD3ECD3GTRACTRGC2
Major Histocompatibility Complex I Genes
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-HMR1
Major Histocompatibility Complex II Genes
CD74HLA-DMAHLA-DMBHLA-DOAHLA-DOBHLA-DPA1HLA-DPB1HLA-DQA1HLA-DQA2HLA-DQB1HLA-DQB2HLA-DRAHLA-DRB1HLA-DRB5IFI30
Other Checkpoint Molecules
ADORA2ABTNL2CD160CD276CD44CD52CD8AHHLA2IDO1IDO1IDO2KIR3DL1KLRD1LAIR1MS4A1NRP1TIGITTMIGD2TNFRSF25TNFRSF8TNFSF15VTCN1
Checkpoint Blockade Therapy Biomarkers
BTLACD274CD274CD80CD8ACSF2CXCL11HAVCR2HLA-DRAHLA-DRB1HLA-DRB5ICOSIFNGLAG3PDCD1PDCD1PDCD1LG2
Immuno Regulatory Gene Signature
ERBB2FASIL5RAINHBATNFRSF8TNFSF4TNFSF9
Immuno Stimulatory Gene Signature
CD160CD19CD200CD27CD44CTLA4HLA-AIL12RB2IL17AKITTNFRSF17
Immuno Suppressive Gene Signature
CD274CD274CD276HAVCR2PDCD1LG2TGFB1
Upregulated in Cancer Vaccination Response
CCL5CD3DCD86CD8ACXCL10CXCL9GBP1ICOSIRF1KLRD1PSMB9STAT1
Immune Cell Markers
CD8 T Cells
CD8ACD8BFLT3LGGZMMPRF1
Th1 Cells
CCL4CD38CD70CSF2CTLA4DPP4IFNGIL12RB2LTASTAT4TBX21
Th17 Cells
IL17AIL17RARORC
Th2 Cells
CXCR6GATA3IL26LAIR2MAFPMCHSMAD2STAT6
Follicular Helper T Cells
BCL6CXCL13MAFPDCD1PDCD1
Other T Helper Cell Markers
ANP32BBATFCD28ICOSNUP107
Regulatory T Cells
FOXP3
Gamma Delta T Cells
CD160FEZ1TRGC1
Central Memory T Cells
ATMDOCK9FYB1NEFLREPS1TXKUSP9Y
Effector Memory T Cells
AKT3CCR2EWSR1IL15RALTKNFATC4
Other T Cell Markers
CD2CD247CD3DCD3ECD3GCD6IL2RBTNFRSF25TRACTRGC2
Myeloid Derived Suppressor Cells
TGFB1
Cytotoxic Lymphocytes
CD3ECD3GCD8ACD8BEOMESGZMAGZMBIFNGKLRC1KLRD1NKG7TBX21
Natural Killer Cells
BCL2CD160FOXJ1FUT5GTF3C1GZMBIL21RKIR3DL1MPPED1NCR1PLA2G6RRADZNF205
Activated Dendritic Cells
CCL1EBI3LAMP3OAS3
Immature Dendritic Cells
CD1ACD1BCD1EF13A1SYT17
Myeloid Dendritic Cells
CD1ACD1BCD1E
Plasmacytoid Dendritic Cells
IL3RA
Other Dendritic Cell Markers
CCL13CCL17CCL22CD209HSD11B1
Macrophages
APOECCL7CD68CHIT1CXCL5MARCOMSR1
Neutrophils
CSF3RFPR2MME
Eosinophils
CCR3IL5RAPTGDR2SMPD3THBS1
Mast Cells
CMA1CTSGKITMS4A2PRG2TPSAB1
B Cells
BANK1BLKCD19CD79ACR2HLA-DOBHLA-DQA1MS4A1PAX5TNFRSF17
Antigen Presenting Cells
CMKLR1
Regulatory T Cell Gene Signature
CD274CD274JAK1PDCD1LG2TIGITTNFRSF18TNFRSF4TNFRSF8TNFRSF9
T Cell Trafficking & Infiltration into Tumors
Stimulates T Cell Trafficking & Infiltration into Tumors
CCL5CX3CL1CXCL10CXCL9ITGB2SELL
Other T Cell Trafficking & Infiltration into Tumors Genes
CCL17CCL4CCR3CCR6CD274CD274CD44CSF2CXCL11CXCL13FOXP3IFNGITGA4ITGB7LTAPDCD1PDCD1PDCD1LG2PTENTNFRSF25TNFSF14
T Cell Exhaustion
Upregulated in T Cell Exhaustion
CCL5CD200CD27CD69CTLA4CXCL10CXCL13GBP1HLA-DMAHLA-DQA1ICOSIFI16IFNGITGAVTAP1TIGITTNFRSF9
Downregulated in T Cell Exhaustion
TNFRSF25
T Cell Exhaustion Transcriptional Nodes
BATFTBX21
Responsiveness or Response Biomarkers
Enhanced Expression in Responsive Versus Nonresponsive Cancers
APPCAPZBCCL4CCL5CD8ACSNK1ECTLA4CXCL10CXCL11CXCL9EBI3EHD1GBA2GZMBHLA-DQA1IDO1IDO1IFNGINHBAIRF2NKG7ODF2PHKG2PPIFPRF1SERPINA3SHMT2SIGMAR1SMAD3TIA1
Suppressed Expression in Responsive Versus Nonresponsive Cancers
ACTG1BNIP3LCX3CL1FOXN3IFI27JAK1LTA4HNAIPOPTNPRRC2BPTENRBL2TXK
Differentially Expressed in Responsive Versus Nonresponsive Cancers
ADAM28AKNAAOAHARHGAP9CACNA2D2CARD11CARD16CD109CLEC11ACORO1ACORO1BCXCR4FLT3FMNL1HIVEP1HIVEP2IFI44LIFITM1IGHA1IGHMIGSF6IKZF1ITPKALSM4LST1MAP3K14NFAM1NFKBIL1PLA2G2DPOU2AF1PTPRCAPSERPINB9SH3BP5SYTL1TMC8TNFRSF13BTNFRSF19ZFYVE9
Expression Correlates with Positive Objective Response Rates
CD274CD274CD276CTLA4HAVCR2IDO1IDO1LAG3PDCD1LG2VTCN1
Upregulated during Treatment
CD8ACTLA4CXCL10EOMESGZMAGZMBICOSIFNGPRF1
Regulated during Treatment
IRF1
Pre-Treatment Response Prediction
Predicts Enhanced Response
ADAM17MYCRHOCTIMP1
Other Pre-Treatment Response Predictors
CDK2CDKN2ALARGE1NAB2NRAS
Cancer Cell Killing
Inhibits Cancer Cell Killing
BTLACD274CD274CD80HAVCR2IDO1IDO1IDO2LAG3MICAMICBPDCD1PDCD1TGFB1VSIRVTCN1
Stimulates Cancer Cell Killing
IFNG
Antigen Processing & Presentation
Proteasome
PSMB10PSMB9
Proteases
IFI30
Endoplasmic Reticulum & Lysosomal Transport
TAP1TAP2TAPBPL
Major Histocompatibility Complex I Genes
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-HMR1
Major Histocompatibility Complex II Genes
CD74HLA-DMAHLA-DQA1HLA-DRAHLA-DRB1HLA-DRB5IFI30
Immune Cell Receptors & Co-Receptors
CD8ACD8BKIR3DL1KLRC1KLRD1
Stimulates Antigen Presentation
CD40CD40LG
Interferon Gamma Response
Cytokines & Chemokines
CCL5IL15RASTAT1
Major Histocompatibility Complex I Genes
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-H
Major Histocompatibility Complex II Genes
HLA-DMAHLA-DQA1HLA-DRAHLA-DRB1HLA-DRB5IFI30
RNA Degradation
OAS3
Transcription Factors
IRF1IRF2
Other Interferon Gamma Response Genes
CD44GBP1
Cytosolic DNA-Sensing Pathway
Cytokines & Interferons
CCL4CCL5CXCL10
Oncogenes
ABL1AKT1ALKARBCL2BRAFCBLCTNNB1DNMT3AEGFRERBB2EZH2FGFR2FGFR3FLT3FOXL2GATA2GNA11GNAQGNASH3-3AH3C2HRASIDH1IDH2JAK1JAK2JAK3KITKRASMAP2K1MED12METMPLMYD88NFE2L2NRASPDGFRAPIK3CAPPP2R1APTPN11RETSETBP1SF3B1SMOSPOPSRCSRSF2TSHRU2AF1
Tumor Suppressor Genes
ACVR1BAMER1APCARID1AARID2ASXL1ATMB2MBCORCDKN2ACICCREBBPDAXXFBXW7KMT2DMLH1NOTCH2PAX5PBRM1PIK3R1PTENRUNX1SMAD2SMAD4SMARCB1STK11WT1
Cell Adhesion Molecules
ABL1APCCSF3RCTNNB1EGFRERBB2JAK2PDGFRAPTENPTPN11RAC1RETRHOASRC
Angiogenesis
CTNNB1ERBB2FGFR2GATA2PIK3CAPLCG1PTENRUNX1
Apoptosis
ABL1APCBCL2BRAFCBLCTNNB1DAXXFLT3FOXL2HRASID3MYCNPTENRAD21RAF1STK11WT1
Cell Cycle
ABL1AKT1APCCDKN2ACHEK2CREBBPCUX1FBXW7FGFR2HRASID3MYCPTENRAD21RHOASMARCB1STK11XPO1
DNA Damage & Repair
ABL1APCATMCHEK2MLH1POLERAD21STK11
Epigenetics
ARID1AARID2ASXL1BCORDICER1DNMT3AEZH2H3-3AH3C2KMT2DNSD2PBRM1SETBP1SMARCB1SPOP
Hypoxia Signaling
CREBBPEPAS1SMAD4
Immune Response
ALKB2MBTKCBLBCD79BCREBBPCXCR4JAK1JAK2JAK3MAP2K1MAP2K2MYD88PAX5PIK3CAPIK3R1PTENPTPN11
Inflammatory Response
CXCR4JAK2MYD88
Metabolism
IDH1IDH2
mRNA Splicing
SF3B1SRSF2U2AF1ZRSR2
Signal Transduction
AKT & PI3 Kinase Signaling
AKT1CBLERBB2FLT3JAK2KITPDGFRAPIK3CAPIK3R1PTEN
Fibroblast Growth Factor Signaling
AKT1FGFR1FGFR2FGFR3FGFR4PIK3CAPIK3R1PTENPTPN11SRC
G-Protein Coupled Receptor Signaling
AKT1GNA11GNAQGNASSMOTSHR
Hormone Receptors
ARESR1
JAK / STAT Signaling
JAK1JAK2JAK3STAT3
MAP Kinase Signaling
MAP2K1MAP2K2MAPK1NRASPPM1DRAF1
Notch Signaling
FBXW7GATA2NOTCH2
Receptor Tyrosine Kinases
ALKEGFRERBB2ERBB3FGFR1FGFR4FLT3KITPDGFRARET
TGFb Signaling
ACVR1BSMAD2
WNT Signaling
AMER1APCCTNNB1MED12PPP2R1A
Other Signal Transduction Genes
KRASMETSMAD4
Transcription Factors
ARCICCUX1ESR1FBXW7FOXL2GATA2ID3MYCMYCNNFE2L2NKX2-1PAX5RUNX1WT1
Ubiquitination
BCORCBLBDAXX
Unfolded Protein Response
NFE2L2
Other Cancer Related Genes
DNM2MPLPRSS1TERT

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